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Gas-vapor decontamination

Gas-vapor decontamination

Whilst the product needs protection from environmental factors, the environment sometimes also needs to be protected from the product, for example when working with pathogenic materials. To prevent the spread of pathogens, it may be necessary to decontaminate a cleanroom. When working with genetically modified organisms (GMOs) and viruses, decontamination of the used materials, equipment and rooms is absolutely vital. The BSL-3 (BioSafety Level 3) guideline applies to organisations working with substances that can cause extremely serious diseases. According to this guideline, outgassing cleanrooms where these substances are used is mandatory. However, companies are increasingly choosing to have also their BSL2 facilities decontaminated by outgassing. These are facilities in which they work with organisms that cause diseases which do not easily spread among the population. Currently, outgassing of cleanrooms with Vapor Hydrogen Peroxide (VHP) is preferred to Formaldehyde.

In practise
For one of its clients, Progress-PME successfully implemented the outgassing of the facilities (cleanrooms and biosafety cabinets) with Vapor Hydrogen Peroxide (VHP). In this project, we chose to use mobile VHP units combined with fixed coupling plates and fixed pipelines for supply and drainage to and from the rooms involved. This gave us optimum flexibility, allowing us to outgas a large number of cleanrooms at the site using VHP.

The project comprised various activities:

  • the purchase and qualification (IQ/OQ) of the required VHP equipment and other utilities, control panel and pipes
  • setting up and implementing cycle development runs
  • PQ qualification runs, during which reduction of potentially present micro flora was demonstrated using biological indicators
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